Parkinson: 200 years in 200 words
Essay on the Shaking Palsy " would change his understanding of what is the second most common neurodegenerative disease. Much has been advanced in these 200 years, but certainly the synthesis of levodopa was the greatest revolution in the treatment of this disease so far. Since then, we have discovered that Parkinson's disease goes far beyond "tremor" in the hands, highlighting the so-called "non-motor" symptoms such as sleep and bowel disorders; we discovered more than a dozen genes implicated in the disease, discovered other medications as dopaminergic agonists, and Parkinson's surgery with electrode implant in the brain has become safe and very effective for selected patients. Of course a lot is yet to come. Soon, for example, we'll have a formulation of levodopa in the form of a nasal spray.
In these 10 years working as a neurologist specializing in neurodegenerative diseases, I learned from my patients countless lessons, especially with my patients with Parkinson's. And perhaps the word that best summarizes what to expect in the next 200 years is hope.
But let it arrive well before ...
The second medicine is Otezla (apremilaste). It is also intended for the treatment of chronic plaque psoriasis, in moderate to severe stages. However, unlike the previous medication, it is indicated for adult patients who have not responded, are contraindicated or are intolerant of other systemic therapies or phototherapy.
Suddenly a sore on the heel or sole of the foot paralyzes movements . The floor is compromised, standing is also painless and the person suffering from the attack needs to be charged. It is the spur, a disease characterized by bone formation caused by the pull of a muscle or tendon with the bone in the region of the heel, knees or elbows, causing inflammation.