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Antidepressants work the same: scientists list the best

Antidepressants work the same: scientists list the best

When it comes to depression, prejudice is very large and there are many doubts about the remedies for this disease: do they make a difference to improve the patient's

A review of 522 studies, published in the scientific journal The Lancet, collected data on 21 different antidepressants, verifying their efficacy.

Overall, the surveys together brought together 116,000 people with depression of both sexes who used medication for at least eight weeks.

The conclusion is that all of them, without exception, were more effective to patients than not using medication. . They are able to reduce symptoms of depression in at least 50%

The most effective antidepressants

Experts made a ranking by comparing the most effective antidepressants in relation to a placebo:

  • Amitriptyline
  • Mirtazapine
  • Duloxetine
  • Venlafaxine
  • Paroxetine
  • milnacipran
  • Fluvoxamine
  • Escitalopram
  • Nefazodone
  • sertraline
  • Vortioxetina
  • agomelatine
  • vilazodone
  • Levomilnacipran
  • Bupropion
  • Fluoxetine
  • Citalopram
  • Trazodone
  • Chloropramine
  • Desvenlafaxine
  • Reboxetine.

However, not all of these remedies are well accepted by patients. The acceptability of data, agomelatine, fluoxetine and escitalopram were the least likely to abandon treatment.

drug efficacy varies from patient to patient

It is important to remember, before looking at this type of ranking, the effectiveness of psychiatric treatments depend on a number of factors. "The psychiatrist must consider that each individual will be no difference in the absorption and distribution of the drug in the body, and the way will be eliminated," says psychiatrist Lucas Gabriel.

And in every person the drug mechanisms of action and relationship between its concentration and the effects achieved will be unique, as the specialist explains. Therefore, treatment for depression and other psychiatric disorders often involves experimenting with various drugs to understand which patient is best suited.


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