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Anvisa approves medicine to treat heart failure

Anvisa approves medicine to treat heart failure

This week, a new class of medicine for treating heart failure will reach Brazilian pharmacies. In May 2017, the National Agency of Sanitary Surveillance (Anvisa) approved the registration of an unpublished medicine for the treatment of heart failure. The remedy Entresto (sacubitril / valsartan) is indicated for adult patients whose symptoms are triggered by daily activities, but also occurring when they are at rest. After the approval of the agency it was decided that a box containing 28 tablets of the drug will cost R $ 147.

Heart failure is a disease in which the heart can no longer pump enough blood to the rest of the body and can not supply its needs.

The drug was adopted by the pharmaceutical market after the good results presented in the PARADIGM study -HF, which involved 8,442 patients with chronic heart failure with reduced ejection fraction (HFER). The researchers found that Entresto significantly reduced the risk of cardiovascular death compared to ACE (angiotensin-converting enzyme) inhibitor 1 enalapril.

According to the research, the compound decreased cardiovascular deaths by 20% in patients, by 21% hospitalizations, a 16% risk of death from all causes and a 20% probability of sudden death, a leading cause of death due to heart failure (HF).

In addition, a study published in 2015 in the journal Archive Brasileiros de Cardiologia, from the Brazilian Society of Cardiology, revealed that about 50,000 people die every year in Brazil from cardiac complications.

The drug product will be manufactured by Novartis Pharma Stein AG located in Switzerland marketed in Brazil by Novartis Biociencias SA


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