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Inspire project seeks to accelerate the diagnosis of lung cancer

Inspire project seeks to accelerate the diagnosis of lung cancer

Lung cancer is the leading cause of death among men and the second among women in Brazil, according to the Ministry of Health. For a long time, the main factor to trigger lung cancer was smoking. It has not been an element of risk for developing the tumor, but it is not the only one.

To get an idea lung cancer rates in non-smokers have doubled in the last 15 years, from 8% to 20 %. Factors such as pollution, second-hand smoke, genetic alterations and exposure to radon, a radioactive gas located in the soil of mineral-rich regions, may increase cancer risk, according to oncologist Marcelo Cruz of the Developmental Therapeutics Program at the Northwestern University Feing Scholl. of lung in the population.

Moreover, one of the reasons that makes lung cancer so harmful is that it is diagnosed, most of the time, at an advanced stage. This is because in the initial phase, it has no symptoms. Thus, when the first signs are manifested, the tumor is already at a more aggressive level.

Another issue is the long period between investigation and diagnosis of the tumor. According to Cruz, the patient's journey, which begins with the investigation of the tumor and goes until receiving the diagnosis, can take about two and a half months. According to him, in addition to causing emotional damage to the patient, this period of uncertainty delays the treatment and may cause the tumor to progress. thus reducing the chances of treatment effectiveness.

Lung cancer can be divided into two major groups:

Small cell lung cancer: it is the cancer that spreads more quickly through the lung. The small cell tumor can be divided into small cell carcinoma and small cell carcinoma combined. Approximately 15% of all lung cancer cases are small cell, being more common in men than women. It is the most aggressive form, usually starting in the bronchi and with high potential to create metastases in other parts of the body, such as brain, liver and bone. Almost all cases occur because of smoking. Check out the Small Cell Lung Cancer Types

Non Small Cell Lung Cancer: This type of lung cancer is divided into three subtypes. There are different types of genes related to non-small cell lung cancer. Check out the non-small cell lung cancer types here.

Inspire

Project As a way to help change this scenario and enable lung cancer patients to have the

The project was developed by the companies AstraZeneca, Briton-Myers Squibb and Pfizer. Each company has developed a specific platform, which contains its own websites, 0800 call centers and partnerships with laboratories. It enables clinicians to make specific requests for tests to their patients and receive the results within 17 days.

Inspire

Features The Inspire project analyzes are intended to help track possible genetic changes in tumors of lung cancer, in order to allow a more assertive diagnosis to the patient.

The platform ID, developed by AstraZeneca, aims to identify if the tumor has the genetic alteration EGFR, a type of protein associated with growth and cell survival expressed in lung cancer tumors. According to the AstraZeneca Brazil and Latin America medical director, Marcelo Horácio, identifying this type of tumor can help to determine if the treatment will be made with specific drugs to prevent the activation of these biomarkers, which can make the treatment more assertive, thus improving the quality of life of the patient.

Another type of genetic alteration may occur in the ALK gene. According to Oncoguia, about 5% of non-small cell lung cancers have a mutation in the ALK gene. This change causes a protein to grow and cause the cells to grow and spread. In view of this, Pfizer will develop the ALK Target test. Pfizer Medical Director Eurico Correia explains that the test seeks to identify the protein present on the surface of lung cancer tumors, allowing the doctor to indicate the best treatment to fight it.

One of the tests performed within the genetic mutations of lung cancer is PD-L1. Inside the Inspire project, it is called I-O Detect and was developed by Bristol-Myers Squibb. BMS Medical Director Roger Shoji Miyake explains that the role of this test is to indicate the likelihood of responding to the treatment of immune-oncology, in order to identify who could be favored of this type of therapy. by means of a tumor analysis.

Accessing the Inspire project

Inspire project exams can be requested by physicians as part of screening for lung cancer screening. It is available for both supplementary network patients and SUS patients. This is because the exams are subsidized by the companies themselves.

According to executives, the Inspire project aims to empower patients. Therefore, if you are more interested in the exams performed on the Inspire project, talk to your doctor.


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