Metabolic syndrome increases risk of developing liver cancer
Hepatology found that the metabolic syndrome significantly increases the risk of developing the initial state of liver cancer, known as hepatocarcinoma (also known as hepatocellular carcinoma). The analysis, conducted by researchers at the National Cancer Institute, United States, and the Goethe-Universität, Germany, used data from SEER-Medicare - a database of cancer patients from the United States. Researchers identified individual diagnoses of hepatocarcinoma (HCC) and cholangiocarcinoma (bile duct cancer, also called CHF) between 1993 and 2005. Sampling used only 5% of the disease cases recorded by the database. Overall, 3649 cases of HCC, 743 CHF and 195,953 cancer-free individuals were observed.
The results revealed that the metabolic syndrome was present in 37% of people who developed HCC and in 30% of those with CHF, compared to 17 % of people who did not have cancer. The analyzes showed that the syndrome was significantly associated with an increased chance of developing hepatocarcinoma and cholangiocarcinoma. Individual factors of metabolic syndrome - hyperglycemia, changes in fat metabolism, obesity, and hypertension - were more common among people who developed HCC or CHF than among people who did not.
The metabolic syndrome comprises a set of conditions, which include the accumulation of fat in the waist (peripheral) and belly (visceral), hypertension, increase in triglyceride levels, blood sugar and bad cholesterol (LDL) and a decrease in good cholesterol (HDL) .
Risks of Metabolic Syndrome
Since the 1980s, frequent diseases such as hypertension, glucose and cholesterol changes were associated with obesity. In addition, all these conditions had one thing in common: insulin resistance. Insulin is critical not only for controlling blood glucose rates, but it works on the liver, fatty tissue, kidneys and blood vessels. In insulin resistance, the individual produces the pancreatic hormone insulin, but this amount - even if adequate - does not act completely, and therefore disrupts the transport of glucose from the blood into the cells, so that it can be used as a source of insulin. In the person with insulin resistance, the body secretes larger amounts of insulin, seeking to "correct" this unbalanced action, but sometimes this mechanism is not efficient and may present as a pre-diabetes state, and to diabetes, driven by the increased concentration of both insulin and glucose in the blood.
All causes of the development of this syndrome have not yet been clarified, but some factors can be facilitators such as the unbalanced diet coupled with a sedentary lifestyle . Already it is known that an irregular diet and lack of physical activity propitiate the increase of cholesterol, with risk of depositing in blood vessels causing atherosclerosis. And, in the growing obstruction of the vessels there may be an increase or worsening of hypertension. On the other hand, studies show that obesity leads to an increase in triglycerides, progression to diabetes and potentially increased atherosclerosis, keeping components of this syndrome always in a cycle that maintains the disease.
What it can cause ?
The importance of the Metabolic Syndrome was due to the finding of its relation with cardiovascular disease. When present, the Metabolic Syndrome is associated with a general mortality two times greater than in the normal population and increases in three times the mortality from cardiovascular causes.
Agência Brasil - Bulletin released on Thursday (25) by the Superintendency of Epidemiological Surveillance of the State Department of Health, reports that since November 18 last year, when notification of pregnant women with red skin patches (exanthema) became mandatory in Rio de Janeiro, 4,746 cases were reported.
A study by researchers at the San Francisco VA Medical Center, USA, shows that more than half of Alzheimer's cases could potentially be prevented with changes in lifestyle and treatment or prevention of this disease. The analysis, published in the journal The Lancet Neurology, made with studies around the world, involved thousands of participants.