New test drug may inhibit Alzheimer's protein
In a survey conducted by the research laboratory A new drug was discovered that could inhibit senile plaques in the brain that would lead to Alzheimer's. The results were published in the journal " Science Translational Medicine ."
The large accumulation of beta-amyloid protein is known to be one of the factors that lead to disease, creating plaques in the brain. The new drug, called verubecestat, works to reduce these plaques, acting directly on the enzyme BACE1, responsible for the appearance of beta-amyloid. Preliminary tests, performed with 32 patients, showed a reduction of up to 80% in levels of this protein. This is not the first time they have tried to create a drug with this function, but so far, all drugs created have had serious adverse effects on patients.
For the first time an oral BACE1 inhibitor drug has been authorized for a new phase involving many patients: about 3,500. Phase 3 of the research should be completed by July 2017 and, if the results remain satisfactory, the pill may be marketed within three years.
Hepatology found that the metabolic syndrome significantly increases the risk of developing the initial state of liver cancer, known as hepatocarcinoma (also known as hepatocellular carcinoma). The analysis, conducted by researchers at the National Cancer Institute, United States, and the Goethe-Universität, Germany, used data from SEER-Medicare - a database of cancer patients from the United States.
The artist took the opportunity to thank the people who were by her side at the moment. "This was something I needed to do for my health.I honestly, I am looking forward to sharing with you on my journey in recent months.Then I want to publicly thank my family and the amazing team of doctors for everything they've done before and after the surgery, "he revealed.
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- The result has resulted in the decrease of HCN-channel proteins, which is associated with depressive behavior.