New test drug may inhibit Alzheimer's protein
In a survey conducted by the research laboratory A new drug was discovered that could inhibit senile plaques in the brain that would lead to Alzheimer's. The results were published in the journal " Science Translational Medicine ."
The large accumulation of beta-amyloid protein is known to be one of the factors that lead to disease, creating plaques in the brain. The new drug, called verubecestat, works to reduce these plaques, acting directly on the enzyme BACE1, responsible for the appearance of beta-amyloid. Preliminary tests, performed with 32 patients, showed a reduction of up to 80% in levels of this protein. This is not the first time they have tried to create a drug with this function, but so far, all drugs created have had serious adverse effects on patients.
For the first time an oral BACE1 inhibitor drug has been authorized for a new phase involving many patients: about 3,500. Phase 3 of the research should be completed by July 2017 and, if the results remain satisfactory, the pill may be marketed within three years.
In Brazil, stuttering affects about 2 million people. In the world this population can reach 70 million. The Oscar-winning film "Speech of the King" in 2011 was a milestone on the subject, as it portrays the process of improving a stutterer's symptoms. When a child has early stuttering, good therapy can greatly improve speech patterns, but healing does not exist.
According to Pan American Health Organization (PAHO), Brazil must face a new outbreak of chikungunya fever over the next few months. The alert was given during the international symposium of the Oswaldo Cruz Foundation (FIOCRUZ), last Tuesday (8). One of the main concerns is due to the rainy season that affects the country during the end of the year, which increase In Pernambuco, for example, from January 3 to July 9, 2016, 31,397 cases of chikungunya were recorded, compared to only 62 occurrences in the same period of According to the Ministry of Health, the latest revision of this number reached 44 thousand cases.
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