New Testosterone Replacement Therapy Applied as Deodorant
Testosterone, produced primarily by the testicles, is the major male hormone. In adult man, his most important actions are associated with sexual functions, such as libido, penile erection, sperm production and maintenance of male characteristics acquired at puberty - hair distribution, muscle and bone development, fat distribution, etc. It has influence, also on the emotions, humor, sensation of well being, muscular tone, among others.
Sexual desire and erection are masculine sexual functions that depend on the sufficient production of testosterone to remain normal. Obviously, it is a hormone with actions of extreme importance. Generally, from the age of 30 there may be a reduction in the amount of testosterone produced by the testicles. Such a reduction varies from one man to another in speed and intensity.
Approximately 15% of men aged 50-60 years exhibit testosterone deficiency. At age 80, about 50% of them show lack of this hormone. The presence of typical symptoms of hormone deficiency, associated with serum levels of testosterone below the reference limits (generally between 300 and 1000 nanograms per deciliter), points to the need for its replacement.
In these cases, the prescription of testosterone is indicated to preserve, among others, the sexual functions, muscle mass, bone mass and the physical and mental well-being of men, since this is a change that significantly reduces the quality of life.
Just spread solution on the underarm skin, as if it were a deodorant
The products available to carry out hormone replacement therapies vary by country. Examples are: oral tablets, subcutaneous implants, transdermal systems, injections and topical gels. In Brazil, testosterone is injected intramuscularly, as well as through gels and skin adhesives. Intramuscular injections available in the country can be applied at intervals of three weeks or three months, while applications on gels or adhesives should be used daily.
The novelty is that a new option is being launched for those who need to replace testosterone. This product was approved by the US Food and Drug Administration (FDA) in 2010, where it is already available. This is a topical solution that will be in our pharmacies soon. The application is simple, painless and easy to enter into the daily habit, since it is enough to spread solution on the skin of the armpits, as if it were a deodorant.
This medicine has the active principle bioidentical testosterone, that is, it is equal manufactured by the human testes. The advantage is that bioidentical testosterone can be dosed in the blood, which greatly facilitates the adjustment of the ideal dose. The bottle contains a device that, when triggered, releases an amount of the solution that corresponds to 30mg of the hormone. The starting dose is 60mg per day, 30mg in each axilla. The subsequent adjustment is done based on testosterone blood levels. It should be noted that this drug should not be used by women, men under 18 years of age and men without hormone deficiency.
Despite progress, it should be noted that male hormone replacement is not risk-free. When well indicated, that is, if there is a lack of fact, testosterone can restore libido, erection, muscle mass, bone mass, body hair, etc.
On the other hand, excessive use as anabolic is high doses of the hormone may be associated with a number of problems, such as increased LDL cholesterol (bad cholesterol), reduced HDL cholesterol (good cholesterol), glucose intolerance, risk of cardiovascular disease, liver tumors, seizures, gynaecomastia (enlargement of the breasts), acne, baldness, enlargement of hair, decreased fertility, etc.
Testosterone replacement therapy is contraindicated in the presence of male breast cancer. The same happens when men already have diagnosed prostate cancer, since the hormone may accelerate the growth of these two types of malignant tumors. For these reasons, rigorous medical monitoring is essential throughout its use. Prostate evaluation (serum PSA and rectal) should be performed both before and during the hormone replacement. In addition, other laboratory tests are periodically needed, including evaluation of the red blood series, serum glucose, cholesterol, and their fractions, triglycerides and testosterone.
Thus, male hormone replacement is important because it improves the quality of life and health of men suffering from this problem but it is clear that medical monitoring is essential in order to ensure both success and safety of treatment.
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