Obesity worsens response to breast cancer treatment

In the treatment of early stage breast cancer, obesity can be a major deterrent. Very overweight women have less time to recur, meaning the cancer can return faster. In conclusion, researchers at Baylor College of Medicine in the United States used data from the Lester and Sue Smith Breast Center, a cancer support center for breast at Baylor College of Medicine. They examined the relationship between weight and modality of treatment in 4,368 patients between 1970 and 1995.

Data revealed that overweight women had similar results to those with normal weight, but those with obesity had a higher risk of recurrence of cancer and greater mortality.

Among patients who did not receive adjuvant chemotherapy or hormone therapy, obesity-related diseases had worse survival outcomes. Among those who received chemotherapy, the results of the group of people with obesity also achieved the worst results.

For researchers, this is because of biological factors associated with being overweight, such as higher levels of estrogen and insulin in the blood, inflammations, and substances secreted by fat cells that facilitate tumor growth.

The exception was treatment with hormone therapy (especially with tamoxifen, widely used in the treatment of early breast cancer), where obesity is thought to be a factor to protect against side effects. Obesity is also a risk factor for cancer

Another article, published in the British Journal of Cancer, points to obesity as being responsible for the most common form of breast cancer in the United States. women. According to the researchers, the disease is even more dangerous than cigarettes and alcohol.

Led by the University of Oxford in the UK, the study looked at health records of about 6,300 postmenopausal women. Knowing that at this stage of life the high levels of the estrogen and testosterone hormones increase two to three times the risk of having breast cancer, they observed which factors influenced this growth.

The results showed that obesity was more influential in the increase hormone levels than other harmful habits, such as alcohol consumption and smoking. In addition, according to researchers, pregnancy, use of contraceptives in pill and menopause also alter the female hormone levels. However, since weight is a possible trait of change, obesity should be at the top of the list.

Although the likelihood of breast cancer is also associated with family history, it is important for women to be aware of how your lifestyle can increase or decrease your risk.

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