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Scientists identify genes that make chemotherapy response difficult

Scientists identify genes that make chemotherapy response difficult

Cancer is one of the most feared diseases today because of its complexity. In the world, breast cancer is the second most frequent type of cancer and the one that affects women the most.

Many breast cancer research is under development in several medical centers worldwide, promoting great advances in prevention, detection A new study by the Southwestern Medical Medical Center of the University of Texas in the United States has identified possible targets that make it difficult to respond to chemotherapy in the treatment of triple negative breast cancer, the most aggressive form of breast cancer . The study was published in the journal Cell Metabolism.

According to the analyzes, increased activity of two genes, MCL1 and MYC, is associated with the development of resistance to chemotherapy. This action boosts mitochondrial oxidative phosphorylation, which promotes the growth of chemotherapy-resistant stem cells. "

" Changes in these two genes are easily detectable in tests for tumor discovery, some combinations of drugs that inhibit MCL1 or MYC, or both have the potential to reduce the development of resistance to chemotherapy and should be studied in clinical trials, "said Dr. Arteaga, Professor of Internal Medicine at UT Southwestern Medical Center. Dr. Arteaga holds the distinguished chair of Lisa K. Simmons in comprehensive oncology.

Most breast cancers can be treated with hormone therapy, but about 15% of cases are triple negative breast cancer, which means that cancer cells are not influenced by hormones such as estrogen or progesterone.

Therefore, triple negative cancer should be treated with chemotherapy, which is toxic to healthy cells as well as cancerous cells. In addition, most triple-negative breast cancers eventually become resistant to chemotherapy and the cancer then spreads unchecked.

According to the team, drugs that inhibit the activity of the MCL1 or MYC genes are under development. When these drugs are given in conjunction with standard chemotherapies, they can potentially delay or even prevent resistance to chemotherapy, improving the prospect of this aggressive form of breast cancer.


A study by researchers at Balgrist University Hospital in Switzerland revealed that when the brain is more difficult to perform multitasking, the researchers found that when faced with a mental challenge while on a walk, men had some change in movement, which is not the case with most women. The study was published in the journal

A study by researchers at Balgrist University Hospital in Switzerland revealed that when the brain is more difficult to perform multitasking, the researchers found that when faced with a mental challenge while on a walk, men had some change in movement, which is not the case with most women. The study was published in the journal "Royal Society Open Science."

The researchers noted that while the walk was normal, all participants swung their left and right arms equally. "When we added the verbal task, we observed that in men of all ages and in women over 60, that symmetry was broken, with a reduction in right arm balance, while the left arm continued to swing normally," the researchers said.

(Health)

Daughter uses the resuscitation technique seen in Gray's Anatomy to save the life of the father

Daughter uses the resuscitation technique seen in Gray's Anatomy to save the life of the father

The American series Gray's Anatomy, which portrays the routine of a team of surgeons performing different types of medical procedures, was an inspiration for an Italian girl to save her father's life from a myocardial infarction. According to information released in the press, infarct at dawn, while the family slept.

(Health)