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Study shows that substance to treat malaria may protect against zika virus

Study shows that substance to treat malaria may protect against zika virus

According to the researchers, hydroxychloroquine, a substance used to treat malaria may be able to effectively block viral transmission to the fetus. Indira Mysorekar, a professor of medicine at the Faculty of Medicine, said the drug is already used in pregnant women to treat malaria and there is hope that it can be used to protect them against the Zika virus. is pregnant, the body uses its antibodies to prevent microorganisms from infecting the fetus. Thus, the placenta is the last line of defense to be reached. However, zika is a virus that can overcome the placenta and reach the fetus.

One of the processes used by the placenta to protect the baby is autophagy, an elimination of the cellular debris itself, in order to ward off microorganisms and organelles In order to understand how the Zika virus reacts to autophagy, the researchers infected human placental cells with zika virus. They then treated the cells with drugs to speed up autophagy, and found, however, that the number of cells infected with the zika virus increased.

According to experts, the virus appeared to be using the body's defenses at

Hydroxychloroquine Performance

Hydrovloroquine has the role of suppressing the action of autophagy. This caused the scientists to start questioning whether she could also protect the fetuses against zika.

To find out if this was possible, they used only mice with a normal autophagic response. The females were infected with zika and then received hydroxychloroquine or placebo for five days. After treatment the scientists found a significantly lower number of viruses in the fetuses and placentas of the mice receiving hydroxychloroquine. The researchers report that both untreated and treated mothers received the same amount of zika in their bloodstream, indicating that hydroxychloroquine was able to protect the fetuses even when the virus circulated by the mother.

Scientists are encouraged by the results, but point out that further studies are needed to ascertain whether hydroxychloroquine is able to function effectively for the treatment of zika virus.


Study advocates the application of fluoride varnish in the prevention of dental caries

Study advocates the application of fluoride varnish in the prevention of dental caries

Want to reduce your children's caries rate by half? New research shows that only one treatment with fluoride varnish per year may be enough to children aged 6 months to 3 and a half. Continue reading on Colgate's website.

(Health)

Women are more sensitive to the effects of alcohol

Women are more sensitive to the effects of alcohol

The Ministry of Health recently released a study entitled "Surveillance of Risk Factors and Protection for Chronic Diseases by Telephone Inquiry 2011 - VIGITEL", which was attended by According to VIGITEL, 17% of Brazilians consumed alcoholic beverages in the BPE pattern, corresponding to 6.2% of the interviewed men and 9.

(Health)