Yellow Fever Vaccine: Ask Your Questions About the Split Amount

Since cases suspected of yellow fever have become common in several regions of Brazil, the demand for the yellow fever vaccine has increased. to meet more people with this immunization, some municipalities of São Paulo, Rio de Janeiro and Bahia will receive the fractional dose of the vaccine as of February.

Since this announcement, several doubts will arise: is it really effective? How does it work? That is why My Life spoke with specialists to clarify all this:

1. What is the fractionated dose of the yellow fever vaccine? The fractionated dose of the yellow fever vaccine is the five-fold division of a standard dose. That is, instead of 0.5 ml, only 0.1 ml will be administered.

Thus, more people will be immunized with the same amount of vaccine, increasing protection.

2. What is the effectiveness of this new fractionated dose?

First of all, it is important to emphasize that the strategy of fractionating the single dose of the yellow fever vaccine is recommended by the World Health Organization (WHO) in situations where there is a risk of the disease expand in cities with a high population index and that had no prior vaccination recommendation.

But does it really protect? "The fractional dose has the same efficacy as the total dose, the difference being that the immunization lasts between 8 and 10 years, that is, after this period, people should be revaccinated," explains the infectologist Marcelo Mendonça, Hospital Santa Paula (SP).

All fractionated doses will be manufactured and distributed by the Institute of Immunobiological Technology of the Oswaldo Cruz Foundation (Biomanguinhos / Fiocruz), the only institution authorized to do so in Brazil. vaccinating 315 people with the fractional dose and realizing that 8 years after this immunization, they still had antibodies to yellow fever.

3. Who needs to take the fractional dose?

People between 2 and 60 years of age, living in 76 municipalities in the States of São Paulo, Rio de Janeiro and Bahia. The other age groups may receive the vaccine after medical evaluation.

See the list of counties below:

4. Who still needs to take the full dose?

According to the immunologist Ana Karolina Barreto B. Marinho, coordinator of the Scientific Department of Immunization of the Brazilian Association of Allergy and Immunology (ASBAI), these groups still need full dose vaccination:

Children between 9 months and 2 years of age

HIV virus carriers with adequate CD4 + cells

Persons who completed chemotherapy and haematological diseases after medical evaluation

• Pregnant women
• Travelers international organizations, whose destinations are countries with compulsory vaccination (must present proof of travel).
• 5. Who can not take any of them?
• People who have ever been vaccinated ever in their lives with yellow fever no longer need to take the
• vaccine. "Additional doses will not give extra protection to the person. Taking the vaccine more than once can lead to hypersensitivity (allergy-like), many of them serious," says Mendonça.

In addition,

who does not live in an area of vaccination recommendation and will not go to these places do not have to worry .

"Yellow fever vaccination is offered in the routine of municipalities with recommended vaccination in the following states: Acre, Amazonas, Amapá, Pará , Rondônia, Roraima, Tocantins, Federal District, Goiás, Mato Grosso do Sul, Mato Grosso, Bahia, Maranhão, Piauí, Minas Gerais, São Paulo, Rio de Janeiro, Espírito Santo, Paraná, Rio Grande do Sul and Santa Catarina. Enumerates Ana Karolina. In addition, the specialist warns groups who should not take the vaccine because of a health risk: People with neoplasms undergoing chemotherapy or radiation therapy

Primary or congenital immunodeficiencies

Previous thymus disease

• People with HIV with a CD4 + T cell count greater than 350
• Autoimmune diseases using immunosuppressants
• Transplanted
• Carriers of severe egg allergy
• In the case of egg allergy, people with mild or moderate be vaccinated. "It is advisable to observe for 30 minutes up to one hour after the application of the vaccine," says the immunologist.
• In severe cases, but at risk of infection with very high yellow fever, an evaluation by the allergist consider desensitization with the vaccine.
• 6. Where the fractional dose will be distributed?

In the municipalities mentioned above it will be possible to find the fractionated doses in the Basic Health Units.

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