Professor Hengli Tang of Florida State University who led the study explained: "It is a first step to a treatment that can stop the transmission of the disease.We focus on the molecules closest to clinical use. " While the Zika-infected cells were examined, the scientists found two types of substances capable of fighting the virus.
The first is niclosamide, an active drug substance already marketed for the treatment of tapeworm (or solitary), blocking the multiplication of the virus. The other is emricasan, an experimental treatment for liver fibrosis, currently used in clinical trials. The latter would be essential in order to prevent the death of the infected cells, since if the organism is taken by the virus and infected cells die, the patient would die together.
The two substances had a representative result after exposure to Zika, especially when were used together. "We still do not have evidence that niclosamide is effective. Clinical studies in animals and humans are still needed," said Hongjun Song, one of the co-authors of the study. . The emricasan drug is still in the process of development and will take some time until it can be used.
The virus has caused an epidemic that already affects 1.5 million people in Brazil. Although it is benign for most people, the disease is responsible for neurological problems and especially severe abnormalities in brain development (microcephaly) in newborns whose mothers have been infected with the virus.
Reducing Zika transmission could also prevent cases of Guillain Barré syndrome (autoimmune disease) and other complications in humans. "Our findings and tools should significantly advance ongoing research on Zika and have an immediate effect on the development of treatments," conclude the scientists.
The central nervous system relates to the digestive tract in a bidirectional way, ie, sending and receiving information, with one influencing the functioning of the other. Environmental thoughts, sensations, and stimuli can affect gastrointestinal motility, secretion and hormone production, immunity, and inflammatory state of the organs.
Both crowns and fixed prostheses are cemented into the tooth as opposed to mobile features such as dentures and partial dentures removable, which can be removed and washed daily. How crowns work? Production of a dental crown - Photo: Getty Images The crown is used for completely or only part of the crown of a damaged tooth.